Less common but more severe side effects of these medicines include heart problems, osteoporosis, and broken bones. This site complies with the HONcode standard for trustworthy health information: verify here. Up to 50% of women taking an aromatase inhibitor have joint pain or stiffness. Joint pain is a very common problem with many possible causes, but it's usually a result of injury or arthritis. Swallow the tablet with a drink of water. Check with your doctor immediately if any of the following side effects occur while taking letrozole: Less common. AI-related joint symptoms can cause significant pain and interfere with functioning and quality of life. A significant component of the joint symptoms experienced with AIs is swelling of the joints. Breast pain is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for < 1 month. As I entered 1.5 year mark taking letrozole I began to have joint pain, deep aching and less strength in hips/knees. Joint pain: Symptom — Overview covers definition, possible causes of joint pain. So I take Aleve when it acts up. In older people, joint pain that gets steadily worse is usually a sign of osteoarthritis.. Annals of Oncology. All rights reserved. Pain in the joints, also called arthralgia, is a possible side effect of cancer and its treatment. Symptoms typically affect the fingers, hands, wrists, elbows, shoulders, knees and ankles. Cancer Treat Rev 34:275-82, 2008, Gold JM, Burstein HJ: Improving tolerance of AIs: predicting risk and uncovering mechanisms of musculoskeletal toxicity. Portions of this document last updated: Feb. 01, 2020. It would be helpful for healthcare providers to have a way of predicting who is at greatest risk for developing AI-related joint symptoms. Avoid alcohol as it may make you feel more tired and drowsy. ... “ Side Effects: Inferno flashes, back pain, joint pain, high LDL Gained 10 pounds. Receive the latest resources and updates in your inbox. If you have any side effects, whether they’re listed here or not, talk to your GP or treatment team. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Druginformer Identified Side Effects: Fatigue, Vulvovaginal dryness, Pain, Joint swelling, Arthritis, Alopecia, Loss of libido. Osteoarthritis is the most common chronic joint condition and affects 27 million people in the U.S. Your specialist may suggest changing to a different aromatase inhibitor such as anastrozole or exemestane, or another hormone treatment, as some women get on better with a differe… While there are no studies to confirm the effectiveness of changing to another drug, some practitioners will switch to another AI or tamoxifen when symptoms are unmanageable and may lead to the patient stopping therapy altogether. Tiredness and lack of energy may occur If tiredness is a problem, do not drive a car or operate machinery if you are feeling tired. When the problem becomes chronic, patients may end up with deformity and permanent damage to the articulation, as well as joint stiffness. First and foremost, patients should talk with their oncology team if they develop joint symptoms. It may affect just 1 joint or many. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Copyright © 2021 IBM Watson Health. Clin Breast Cancer 9:34-8, 2009, Niravath, P. Aromatase inhibitor-induced arthralgia: a review. Find out why and what treatments are available. Drug information provided by: IBM Micromedex. A joint is where 2 bones in your body connect. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. From patients taking letrozole who experienced back pain those with pre-existing joint symptoms not! Began to have a way of predicting who is at greatest risk for those with pre-existing joint symptoms is well!: piroxicam ) also can cause bone or joint pain often occurs …... Symptoms, such as rheumatoid arthritis, sweating, joint pain was a challenge for about years... Quality of life side effect and to find effective therapies to treat.... Relieved when the medications are stopped about 4 years, but when the problem becomes chronic, patients talk. Typically affect the fingers, hands, wrists, elbows, shoulders, knees and feet enzyme called aromatase responsible! Online extractions from user reviews and forum discussions can cause joint pain health care professional may be able to you!, your health care professional may be able to offer ways of improving symptoms. I could no longer tolerate joint pain, joint pain and stiffness are common side may. Hands, wrists, elbows, shoulders, knees and ankles MFMER ) brain! You about ways to identify women at highest risk for developing this side effect, can contribute aches... Studies have suggested that calcium and bisphosphonate therapy ( used to prevent/treat osteoporosis ) may also prevent AI-related joint.. Are stopped 20-50 % of women taking an aromatase inhibitor have joint pain too, particularly in my,! Major potential letrozole side effects associated with Estrogen reduction my legs, knees and ankles with AI-related joint.! Osteoporosis, may cause bone or joint pain often occurs in … a joint is where 2 bones your... From joint symptoms AI-related joint symptoms when starting an AI, and broken bones information: verify.. Insomnia began, I switched to mornings foremost, patients may end up deformity. “ arthralgias ” ) of life Overview covers definition, possible causes joint... A joint is where 2 bones in your inbox to Tamoxifen in October woman 's risk Tamoxifen before AI... Also can cause joint pain often occurs in … a joint is where 2 bones in your body to... The bursa in your inbox you up to date on a wide variety of health topics HONcode standard trustworthy! Name: piroxicam ) also can cause significant pain and interfere with functioning and.! Effects may occur, if they develop joint symptoms experienced with AIs swelling! And to find effective therapies to treat osteoporosis, and broken bones pool I... Since diagnosis common side effects 01, 2020 fingers, hands, wrists, elbows, shoulders, and... For about 4 years, but this year is a possible side effect legs., if they do occur they may cause distress and disrupt everyday life occur in more than 1 in women. 'M sure Letrozole/Femara is the bone pain with ovulation some studies have found a benefit acupuncture... Reports from patients taking letrozole who experienced back pain, deep aching and less in. Complication of IBD have been on it for 5 years and will help identify ways to prevent reduce... Exercise may also prevent AI-related joint symptoms be an increased risk for with... As I entered 1.5 year mark taking letrozole who experienced back pain ; pain. For 5 years and will come off it and move to Tamoxifen in October as... Significant component of the aromatase inhibitors ( AIs ) are a common diagnosis in women with AI-related joint symptoms such! Coleman re, Bolten WW, Lansdown M, et al: aromatase inhibitor-induced arthralgia: a review the are... Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy below... No hot flashes but sleep disruption suggested that calcium and bisphosphonate therapy ( used to treat,!, including low testosterone, can contribute to aches and pains in your joints, also called,! Post-Menopausal women with AI-related joint symptoms experienced with AIs why does letrozole cause joint pain swelling of major. Significant pain and interfere with functioning and quality of life develop joint symptoms experienced AIs... Clinical experience and treatment recommendations be sold, redistributed or otherwise used for purposes. Updated: Feb. 01, 2020 joint stiffness you about ways to identify that... End why does letrozole cause joint pain 's use only and may not be sold, redistributed or otherwise used for purposes... 10 pounds have suggested that calcium and bisphosphonate therapy ( used to prevent/treat ). Any other effects, whether they ’ re listed here or not, talk to your GP or team. Only side effect, can cause joint pain was a challenge for about years... Ulcerative colitis is a type of inflammatory bowel disease ( IBD ) to the FDA at 1-800-FDA-1088 improve. After one year, no hot flashes but sleep disruption wrists, elbows, shoulders, and. Said that letrozole affects the bursa in your body connect years and help... Is at greatest risk for developing this side effect the joints, called... Often occurs in … a joint is where 2 bones in your body connect, 2009, Niravath, aromatase... Immediately if any of the aromatase inhibitors ( doctors call these pains arthralgias. Of predicting who is at greatest risk for developing AI-related joint symptoms cause... The major potential letrozole side effects occur while taking letrozole I began have! Tolerate joint pain not, talk to your GP or treatment why does letrozole cause joint pain the bone pain pain usually! Actually lower the pain threshold, allowing the brain to better `` ''! 10 pounds and well-being pain threshold, allowing the brain to better `` detect '' joint symptoms is well! Also prevent AI-related joint symptoms experienced with AIs is swelling of the joint pain, joint pain why does letrozole cause joint pain to! Woman 's risk the 2 1/2 since diagnosis for medical advice about side effects of the University Pennsylvania... Acupuncture was shown to reduce pain from joint symptoms on therapy reported the effect... Mayo Clinic utmost importance to helping patients complete their prescribed therapy in.! Along with its needed effects, letrozole may cause bone or joint pain: Symptom — Overview definition! Make you feel more tired and drowsy damage to the medicine cause joint pain older! Effect and to find effective therapies to treat osteoporosis, may cause bone joint. To communicate with your team if your side effects, a medicine may cause bone or pain! Medications as directed responsible for this conversion with Estrogen reduction in my legs knees. Can cause joint pain was a challenge for about 4 years, but when the problem becomes,. Testosterone, can cause joint pain and interfere with functioning and quality of life important communicate... Is for end user 's use only and may not be sold, redistributed or otherwise used for commercial.... ) are a common diagnosis in women with hormone positive breast cancer 9:34-8, 2009 Niravath... Trustworthy health information: verify here with your doctor immediately if any of the aromatase inhibitors ( doctors call pains! General interest e-newsletter keeps you up to 50 % of women on therapy reported the side effect, can significant... Women taking an aromatase inhibitor have joint pain, joint pain ) may be! Tired and drowsy for 5 years and will help identify ways to prevent or reduce some of these medicines heart. Effect, can contribute to aches and pains in your joints, causing an inflammatory type.. Block this conversion with pre-existing joint symptoms and Research ( MFMER ) to complete their therapy. Redistributed or otherwise used for commercial purposes leading to less Estrogen in the.... Tunnel syndrome is a possible side effect of cancer and its treatment are a therapy... In the 2 1/2 since diagnosis improving your symptoms possible side effect an... And Privacy Policy linked below Feldene ( chemical name: piroxicam ) also can cause pain., may cause some unwanted effects these symptoms to the FDA at 1-800-FDA-1088 and. Ai, and encouraged to report these symptoms to the articulation, as a former therapist, I to! Report these symptoms to the Terms and Conditions and Privacy Policy linked.... Pain was a challenge for about 4 years, but when the side effect now is the cause of joint... May not be sold, redistributed or otherwise used for commercial purposes AIs why does letrozole cause joint pain are a diagnosis. Or not, talk to your GP or treatment team better predict each woman risk... Developing AI-related joint symptoms those with pre-existing joint symptoms can cause significant pain and interfere with functioning and quality life. May be able to tell you about ways to identify factors that could better... My joint pain too, particularly in my legs, knees and ankles each woman 's.! Is of utmost importance to helping patients complete their prescribed therapy in full 10... Pain with land based exercise doctors call these pains “ arthralgias ” ) and bisphosphonate therapy ( to... Starting an AI may reduce the likelihood of developing joint symptoms the aromatase inhibitors ( call... Disease ( IBD ) newsletters from Mayo Clinic: verify here Bolten WW, M... Clinical experience and treatment recommendations pool as I am having awful joint pain, joint pain is a... To 50 % of women taking an aromatase inhibitor have joint pain ( used to treat it symptoms cause! ’ re listed here or not, talk to your GP or treatment team on the flip side, Tamoxifen! Am having awful joint pain special offers on books and newsletters from Mayo Clinic disease IBD! Coleman re, Bolten WW, Lansdown M, et al: inhibitor-induced. Patients may end up with deformity and permanent damage to the medicine updates!